Like an awful lot of people right now, I'm kind of obsessed with the magical thing called "proteogenomics". Which...honestly...seems a little bit like magic. Getting good quality transcriptional data and filtering it so that you can see new mutations....that you can trust...AND THEN using this information to find new matches to your MS/MS data....that you can trust....
A few people have totally pulled it off....and I have the papers stacked up in front of my PC all marked up and highlighted and...well...maybe I'm dumb...but I still don't know how they did it.
For a good starting point, check out this nice review from Sam Faulkner et al.,. While I'm on the topic of magic, you might be surprised to see this is an article from Springer that isn't behind a paywall!
Oh yeah! And here is the link!
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