Is offline fractionation hurting us more than its helping?

This is interesting -- and deserves more time than I can give it on a lunch break.

Its out of something called the Yates lab. Seems familiar, somehow...

The paper is called: "Off-Line Multidimentional LC and Auto Sampling Results in Sample Loss in LC/LS-MS/MS" and you can give it more time (appears open access! here)

Interesting, right?